How are some synapses eliminated during development

This week in neuron, yasuda and colleagues investigated how inactive synapses are eliminated in the brain during development.Frequently tend to have the largest motor units and thus undergo the least amount of synapse elimination during development.Synapse elimination is a normal developmental process occurring throughout the central and peripheral nervous systems.At the neuromuscular junction, synapses compete for innervation of a muscle fiber.Meanwhile, gradual and early loss of synapses is a characteristic that is.Humans have the most synapses at the ages of 12 to 16, and from then to about age 20, there is net synapse elimination that is a normal part of the.

Synaptic contacts are generated in excess during the early phase of development.This process may underlie the progressively restricted malleability of the maturing nervous system.Many synapses are eliminated after an initial phase of synapse formation.Polyinnervation takes place during the first phases of development, creating a great number of synapses.Some synapses are eliminated during development.